HKEY_CURRENT_USER\SOFTWARE\Microsoft\Office\15.0\Common\Identity These keys are needed to enable MFA in Outlook 2013
If you need to create an app password, create a new at Create Office 365 App Password. You can set a registry key on your home computer to enable MFA in Outlook. Not all programs support MFA at this time, so you may not be able to avoid using App passwords completely, but you don't need app passwords with Outlook 2013 or 2016. I don't have problems using Outlook and MFA at work (with an Office 365 Enterprise license) but at home I need to use an app password in Outlook 2016 from my Home Premium subscription. Multi Factor auth is enabled on my Office 365 account.